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Sotax Dissolution Testing
The dissolution rate of a drug from the solid state is defined as the amount of drug substance that goes into solution per unit time under standardized conditions of liquid/solid interface, temperature and solvent composition
Detailed below are explanations of the different systems, from manual to fully automated dissolution, which we supply from Sotax
The workhorse for every dissolution laboratory designed with the Autocompliance™ concept which eliminates daily routine validation. The SOTAX AT7 Smart Dissolution Bath can be used as a standalone unit or upgraded to a semi-automated system. Click here for more information on Manual Dissolution Testing |  |
To automate sampling or analysis a Semi-Automated Dissolution Testing System is used. Samples can be taken simultaneously, filtered and collected in a fraction collector, withdrawn using a robotic arm or simultaneously sampled and analyzed directly by UV or HPLC. It is also possible to collect a sample as well as analyzing at the same time. Dissolution test can also be performed in situ by a fiber optic probe also called UV-FO. The operator will fill the vessels with media, the tablets will be automatically dropped and the test will start and finish. Once the test has been completed, the operator will clean the system for the next test. |  |
Based on the ever evolving AT7 Smart dissolution bath various possibilities are offered according to your specific needs: Off-line system: AT7 Smart with pump and fraction collector On-line system: AT7 Smart with pump and UV Spectrophotometer On-line system: AT7 Smart with pump, transfer station and HPLC AT7 Smart with automated sampling device (ASD) AT7 Smart with fibre optic Click here for more details on Smart Semi-Automated Dissolution Testing | |
For a completely Automated Dissolution process for multiple unattended tests, including media preparation and delivery, automated dosage introduction, automated sampling, filtering and sample analysis by UV, HPLC, or UVFO, and vessel cleaning then a Fully Automated Dissolution Testing System, also called fully Automated Dissolution Tester, can be used. The operator would only load the samples and collect the dissolution reports. The test can be done with paddles on tablets, capsules in sinkers and pellets in cartridges or with capsules in baskets. 2 base configurations are available: AT70 For USP 2 paddles testing AT70 with BS60 for USP 1 & 2 paddles and basket testing Click here for more details on Smart Fully Automated Dissolution Testing |  |
The CE 7smart is the fourth generation of SOTAX flow-through cell systems and has been designed as the Apparatus 4 instrument made to overcome potential challenges linked to method development for a variety of dosage forms. Based on the base CE7 Smart dissolution bath various possibilities are offered according to your specific needs. Manual CE7 Smart USP 4 Off-line Closed system USP 4 Off-line Open system USP 4 On-line systems Click here for more information on CE7 Smart USP 4 Flow Through Tester |  |
Automate the preparation of you dissolution media in an accurate and repeatable manner |  |
Any further questions? Please contact: sotax@carlstuart.com